Dax Ryan Locke, born on June 26, 2007 to Julie and Austin Locke, had been diagnosed with AML M7 when he was 13 weeks old. The core of Christmas is set in Washington, Illinois and at St. Jude Children's Research Hospital, among the world's premier centres for its research and treatment for esophageal cancer and other deadly diseases in children. Told in flashback from the point of view of Megan (Candace Cameron Bure), a successful businesswoman, wife and mother of two, the storyline unfolds when her commitment to faith and family has been renewed after reading the blog of Julie Locke, (http://www.caringbridge.org/visit/daxlocke), the web diary that Julie maintained after Dax was diagnosed with Acute Myeloid Leukemia (AML) (http://theheartofchristmasmovie.com/story.php).