Spides is a science fiction series about Nora (Rosabell Laurenti Sellers), a young woman from Berlin who awakens from a coma and has lost all memory after using a new party drug. When Nora learns that countless youths have gone missing as a result of the spread of the party drug "Bliss," she conducts an investigation with Nique Navar (Florence Kasumba) and David Leonhart (Falk Hentschel). She unearths an unsettling conspiracy: Aliens utilize the medication to take up residence in the bodies of their victims. Nora becomes increasingly entangled in the bizarre happenings and comes to believe that she is the key to defeating the alien invasion.