Sheena parents are murdered while. An African tribe's mystical witch woman raises her. When her foster mum is framed for the murder of a governmental pioneer, Sheena and a newsman, Vic Casey are made to flee while chased by the mercenaries hired by the actual killer, who expects to assume power. They are given an opportunity against the superior tech weapons of this mercenaries by the capacity to speak with the critters and knowledge of jungle lore of sheena.