Edward and Alphonse Elric's reckless disregard for alchemy's laws cut off half of Ed's limbs and left Al's soul in a suit of armor. To repair what was lost, the brothers search for the Philosopher's Stone, a fabled relic that offers inconceivable alchemy powers. The corrupt State Military is also after the artifact's power. So are the Homunculi and their maker. Mythical jewel scars alchemists from faraway nations, inspiring some to murder. While opponents and allies alter the Elrics' route, their purpose stays unchanging and their relationship unshakable.