For a cure for Alzheimer's disease, a team of scientists are currently searching on a remote former submarine refueling facility named Aquatica. Dr. Susan McAlester genetically engineers Mako sharks, going to improve their brain capacity in order they are able to harvest the tissue for a cure for Alzheimer's. Unfortunately, the higher brain capacity makes the sharks more threatening, and fuller, faster. Aquatica's financial backers also ship a corporate executive to go to the facility, and are nervous and skeptical about the evaluations.