Yakko and Wakko Warner, as well as Dot, have a great time wreaking havoc and mayhem in the lives of everyone they come across. After being welcomed back home by the Warner Bros. Water Tower, the Animaniacs waste no time in wreaking mayhem and comedic confusion as they run amok throughout the studio and beyond, transforming everything into their own personal playground. The reappearance of Pinky and the Brain, two fan-favorite characters, will help Yakko, Wakko, and Dot in their ongoing quest for world dominance.